Carpentier-Edwards ThermaFix Process: A Method for Extracting Calcium Binding Sites from Pericardial Tissue
نویسنده
چکیده
Glutaraldehyde fixation is a tissue preservation process used in the manufacture of bioprosthetic heart valves. The objective of fixation is to produce stable, durable, and biologically inert tissue that is suitable for implantation. Collagen, a principle tissue protein, provides strength and resistance to breaking stresses in tissue and plays a critical role in its long-term durability. In 1982, Edwards Lifesciences developed a proprietary glutaraldehyde fixation process for bioprosthetic tissue. Edwards Neutralogic fixation utilizes a low pressure method of fixation that helps to preserve the natural elasticity of the collagen matrix. Neutralogic fixation allows glutaraldehyde to form crosslinks with collagen that result in durable fibrous tissue structures that have long-term performance properties that are well suited for bioprosthetic heart valve tissue.
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